SGOT, SGPT, LDH & GGT

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Alanine transaminase (ALT/SGPT) : SGPT is elevated in acute hepatitis of viral or toxic origin, jaundice and cirrhosis of liver (normal 3-40 IU/L).

Aspartate transaminase (AST/SGOT) : SGOT activity in serum is increased in myocardial infarction and also in liver diseases (normal 4-45 IU/L).

SGPT is more specific for the diagnosis of liver diseases while SGOT is for heart diseases. This is mainly because of their cellular distribution - SGPT is a cytosomal enzyme while SGOT is found in cytosol and mitochondria.

Lactate dehydrogenase (LDH): LDH is useful for the diagnosis of myocardial infarction, infective hepatitis, leukemia and muscular dystrophy (serum LDH normal 50-200 IU/L). LDH has five isoenzyme.

gamma-Glutamyl transpeptidase (GGT) : lt is a sensitive diagnostic marker for the detection of alcoholism. GGT is also increased in infective hepatitis and obstructive jaundice.

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